Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation

2009; Public Library of Science; Volume: 4; Issue: 6 Linguagem: Inglês

10.1371/journal.pone.0006007

ISSN

1932-6203

Autores

Leandro Slipczuk, Pedro Bekinschtein, Cynthia Katche, Martı́n Cammarota, Iván Izquierdo, Jorge H. Medina,

Tópico(s)

Receptor Mechanisms and Signaling

Resumo

The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control of a subset of mRNAs through regulation of its initiation step. In neurons, mTOR is present at the synaptic region, where it modulates the activity-dependent expression of locally-translated proteins independently of mRNA synthesis. Indeed, mTOR is necessary for different forms of synaptic plasticity and long-term memory (LTM) formation. However, little is known about the time course of mTOR activation and the extracellular signals governing this process or the identity of the proteins whose translation is regulated by this kinase, during mnemonic processing.

Referência(s)