Portal de Periódicos da CAPES

Kashin-Beck disease and iodine deficiency in Tibet

2001; Springer Science+Business Media; Volume: 25; Issue: 3 Linguagem: Inglês

10.1007/s002640000216

1432-5195

Rodrigo Moreno‐Reyes, C. Suetens, Françoise Mathieu, F. Begaux, Dun Zhu, T. Rivera, Marleen Boelaert, Jan‐Walter De Neve, N. Perlmutter, Jean Vanderpas,

Neonatal Health and Biochemistry

We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.