Synthesis of 1,3-dioxin-4-ones having chiral hydroxyalkyl groups at the 6-position by means of baker's yeast reduction and their uses for epc synthesis

Artigo Revisado por pares

Synthesis of 1,3-dioxin-4-ones having chiral hydroxyalkyl groups at the 6-position by means of baker's yeast reduction and their uses for epc synthesis

1991; Elsevier BV; Volume: 47; Issue: 32 Linguagem: Inglês

10.1016/s0040-4020(01)86552-2

ISSN

1464-5416

Autores

Junichi Sakaki, Yoshiaki Sugita, Masayuki Sato, Chikara Kaneko,

Tópico(s)

Asymmetric Synthesis and Catalysis

Resumo

Prochiral methyl ketones connected with 6-(4-oxo-1,3-dioxinyl) group directly or through methylene chain (1–3) gave, by treatment with fermenting baker's yeast, the corresponding (S)-alcohols which served as synthons for a variety of enantiomerically pure compounds.

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Synthesis of 1,3-dioxin-4-ones having chiral hydroxyalkyl groups at the 6-position by means of baker's yeast reduction and their uses for epc synthesis