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Studies of lactose absorption in patients with galactosemia

1967; Elsevier BV; Volume: 71; Issue: 1 Linguagem: Inglês

10.1016/s0022-3476(67)80234-8

1097-6833

Maurice D. Kogut, George N. Donnell, Kenneth N.F. Shaw,

Polyamine Metabolism and Applications

Ten patients with galactosemia and six control subjects were given oral lactose loads. Only one child, a patient with galactosemia, failed to hydrolyze lactose and absorb its monosaccharide components. Nine of ten patients with galactosemia hydrolyzed lactose in spite of the fact that lactose had been excluded from their diet since early infancy, which suggested that intestinal lactase does not appear to be dependent upon lactose intake. The results of the sugar tolerance tests and of jejunal enzyme studies indicated that one of the children with galactosemia had an isolated lactase defect. Ten patients with galactosemia and six control subjects were given oral lactose loads. Only one child, a patient with galactosemia, failed to hydrolyze lactose and absorb its monosaccharide components. Nine of ten patients with galactosemia hydrolyzed lactose in spite of the fact that lactose had been excluded from their diet since early infancy, which suggested that intestinal lactase does not appear to be dependent upon lactose intake. The results of the sugar tolerance tests and of jejunal enzyme studies indicated that one of the children with galactosemia had an isolated lactase defect.