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Monoclonal immunoglobulin deposition disease: A review of immunoglobulin chain alterations

1994; Elsevier BV; Volume: 16; Issue: 5-6 Linguagem: Inglês

10.1016/0192-0561(94)90032-9

1879-3495

Jean‐Louis Preud'homme, Pièrre Aucouturier, Guy Touchard, Ahmed Amine Khamlichi, Anna Rocca, Luc Denoroy, Michel Cogné,

Blood properties and coagulation

Monoclonal immunoglobulin deposition disease, a complication of overtly malignant or apparently benign immunoproliferative disorders, is a severe disease featuring tissue deposition of monoclonal light, light and heavy, or heavy chains. A number of converging arguments strongly suggest a direct pathogenetic role of structural abnormalities or peculiarities of variables regions of light and/or heavy chains (associated with deletions in the constant region for the heavy chains). Recent structural data on these abnormal immunoglobulin chains are reviewed.