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Fármacos multifuncionais: monoamina oxidase e α-sinucleína como alvos terapêuticos na doença de Parkinson

2013; Brazilian Chemical Society; Volume: 36; Issue: 2 Linguagem: Inglês

10.1590/s0100-40422013000200017

1678-7064

Cristian Follmer, Heleno J. C. Bezerra Netto,

Enzyme Catalysis and Immobilization

OF PARKINSON´S DISEASE.Parkinson's disease (PD) is a neurodegenerative disorder associated to selective degeneration of dopaminergic neurons caused by an intricate relationship among dopamine metabolism, oxidative stress and a-synuclein fibrillation.Most therapies for PD have focused on dopamine replacement through the use of both monoamine oxidase inhibitors (MAOIs) and dopamine precursor L-dopa.Interestingly, certain MAOIs have a broad spectrum of action including anti-fibrillogenic properties in a-synuclein aggregation.Herein we revisit the chemical properties of MAOIs and their action on important targets associated with PD, notably a-synuclein fibrillation and dopamine metabolism, discussing the strategies associated with the development of multitarget drugs for neurodegenerative diseases.