Produção Nacional
Revisado por pares
Natriuretic and diuretic effects of Tropaeolum majus (Tropaeolaceae) in rats
2009; Elsevier BV; Volume: 122; Issue: 3 Linguagem: Inglês
10.1016/j.jep.2009.01.021
ISSN1872-7573
AutoresArquimedes Gasparotto, Marcos Aurelio Boffo, Emerson Luiz Botelho Lourenço, Maria Élida Alves Stefanello, Cândida Aparecida Leite Kassuya, Maria Consuelo Andrade Marques,
Tópico(s)Complementary and Alternative Medicine Studies
ResumoTropaeolum majus L. (Tropaeolaceae), popularly known as "chaguinha", is well recognized in Brazilian traditional medicine as diuretic agent, although no scientific data have been published to support this effect.To evaluate the diuretic activity of the infusion and the hydroethanolic extract (HETM) of Tropaeolum majus, and possible mechanism of action.The infusions (2,5 - 10%) and the HETM doses (150, 300 mg/kg) were orally administered to rats. Urinary excretion, the electrolytes levels, and urea and creatinine were measured in of saline-loaded rats.The oral administration of 10% (corresponding to 500 mg/kg) of the infusion increased significantly the urinary Na(+) excretion. Only the oral administration of 300 mg/kg of HETM increased significantly the urinary and Na(+) excretion. Prolonged administration of the HETM (300 mg/kg) significantly increased diuresis and the urinary excretion of Na(+), but others parameters were unaffected. To gain some evidence in possible involvement of prostaglandins system in diuretic action, the oral administration of HETM (300 mg/kg) in association indomethacin (5mg/kg) reduced the urinary and sodium excretion when compared only HETM group.The results suggest that HETM could present compound(s) responsible for diuretic activities with no signs of toxicity, and the mechanism could involve prostaglandin system.
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