Strategies for bypassing the membrane barrier in multidrug resistant Gram‐negative bacteria
2011; Wiley; Volume: 585; Issue: 11 Linguagem: Inglês
10.1016/j.febslet.2011.04.054
ISSN1873-3468
AutoresJean‐Michel Bolla, Sandrine Alibert, Jadwiga Handzlik, Jacqueline Chevalier, Abdallah Mahamoud, Gérard Boyer, Katarzyna Kieć‐Kononowicz, Jean‐Marie Pagès,
Tópico(s)Antimicrobial Peptides and Activities
ResumoRegarding bacterial susceptibility towards antibacterial agents, membrane permeability is part of the early bacterial defense. The bacterium manages the translocation process, influx and efflux, to control the intracellular concentration of various molecules. Antibiotics and biocides are substrates of these mechanisms and the continuing emergence of multidrug resistant isolates is a growing worldwide health concern. Different strategies could be proposed to bypass the bacterial membrane barrier, comprising influx and efflux mechanisms, in order to restore the activity of antibiotics against resistant bacteria.
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