An improved synthesis of 3,6‐diamino‐1,2,4,5‐tetrazine. I
1990; Wiley; Volume: 27; Issue: 7 Linguagem: Inglês
10.1002/jhet.5570270717
ISSN1943-5193
AutoresMichael D. Coburn, Donald G. Ott,
Tópico(s)Quinazolinone synthesis and applications
ResumoAbstract Treatment of 1,3‐diaminoguanidine monohydrochloride ( 1 ) with 2,4‐pentanedione ( 2 ) in alcohols under carefully controlled conditions gave 3,6‐diamino‐1,2‐dihydro‐1,2,4,5‐tetrazine monohydrochloride ( 3 ) in 45‐50% yields along with 3,5‐dimethyl‐1 H ‐pyrazole ( 4 ) and its hydrochloride 5 . Oxidation of 3 with sodium perborate produced 3,6‐diamino‐1,2,4,5‐tetrazine ( 6 ) in quantitative yield.
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