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Morphology and pathogenesis of Liesegang rings in cyst aspirates: Report of two cases with ancillary studies

1998; Wiley; Volume: 19; Issue: 2 Linguagem: Inglês

10.1002/(sici)1097-0339(199808)19

8755-1039

Dominic S. Raso, William B. Greene, James L. Finley, Jan F. Silverman,

Forensic Entomology and Diptera Studies

Liesegang rings are laminated ring-like structures occasionally found in benign cysts and abscesses. They have been confused with parasites (especially eggs), algae, calcifications, and psammoma bodies. We examined Liesegang rings from fine-needle aspiration (FNA) biopsies of a benign cyst of the breast and a complex renal cyst. Liesegang rings were best observed with Papanicolaou, hematoxylin-eosin, Masson's trichrome, acid-fast (AFB), and Gram stains, which accentuate the concentrically laminated morphology. An amorphous electron-dense core and fibrillary lucent concentric rings were seen with transmission electron microscopy with no significant energy peaks by electron probe microanalysis or distinct diffraction patterns by X-ray diffraction. This investigation indicates that Liesegang rings are composed of organic substances most likely formed by periodic precipitation from a supersaturated solution within cystic fluid. Awareness of the Liesegang phenomenon within cystic lesions will decrease the possibility of erroneous misdiagnosis as another type of pathologic process. Diagn. Cytopathol. 1998;19:116–119. © 1998 Wiley-Liss, Inc.