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INVASION OF SCHWANN CELLS INTO THE SPINAL CORD OF THE RAT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN

1976; Wiley; Volume: 2; Issue: 1 Linguagem: Inglês

10.1111/j.1365-2990.1976.tb00559.x

1365-2990

W. F. Blakemore,

Biochemical effects in animals

NVASION OF SCHWANN CELLS INTO THE SPINAL CORD OF THE RAT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN Focal areas of primary demyelination were induced in the spinal cord of rats by local injection of lysolecithin. In addition to loss of myelin there was also loss of astrocytes and oligodendrocytes in some parts of the demyelinated area. All demyelinated axons were subsequently remyelinated either by oligodendrocytes or by Schwann cells. Schwann cells remyelinated axons in the centre of the lesion and beneath the pia; the remaining axons were remyelinated by oligodendrocytes. By three months after the lesion the two types of remyelinated fibres were always separated from each other by astrocytes covered by basement membrane. It was concluded that the glial limiting membrane (basement membrane‐covered astrocytes) normally inhibits Schwann cell entry into the spinal cord. When this is destroyed they can enter, but when it becomes re‐established their free migration into the neuropil is once again inhibited.