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Anticholinesterase activity of elapid venoms

1973; Elsevier BV; Volume: 11; Issue: 2 Linguagem: Inglês

10.1016/0041-0101(73)90074-3

1879-3150

Vijay Kumar, Thomas A. Rejent, W.B. Elliott,

Computational Drug Discovery Methods

Of 16 elapid venoms from Naja, Bungarus, Ophiophagus, Dendroaspis, Hemachatus and Notechis species, only Notechis scutatus venom totally lacked anticholinesterase activity while N. nigricollis, M. fulvius, D. jamesoni, D. polylepis and D. angusticeps lacked acetylcholinesterase activity. Zinc ions were necessary for anticholinesterase activity; cobaltous ions being less effective in restoring anticholinesterase activity, while magnesium, nickelous, stannous and manganous ions were inactive. Notechis scutatus and to a lesser extent Dendroaspis jamesoni venom enhanced the acetylcholinesterase activity of Bungarus fasciatus venom when incubated together in the presence of zinc.