Portal de Periódicos da CAPES

Sara Endosomes and the Maintenance of Dpp Signaling Levels Across Mitosis

2006; American Association for the Advancement of Science; Volume: 314; Issue: 5802 Linguagem: Inglês

10.1126/science.1132524

1095-9203

Christian Bökel, Anja Schwabedissen, Eugeni V. Entchev, Olivier Renaud, Marcos González‐Gaitán,

Hippo pathway signaling and YAP/TAZ

During development, cells acquire positional information by reading the concentration of morphogens. In the developing fly wing, a gradient of the transforming growth factor-beta (TGF-beta)-type morphogen decapentaplegic (Dpp) is transduced into a gradient of concentration of the phosphorylated form of the R-Smad transcription factor Mad. The endosomal protein Sara (Smad anchor for receptor activation) recruits R-Smads for phosphorylation by the type I TGF-beta receptor. We found that Sara, Dpp, and its type I receptor Thickveins were targeted to a subpopulation of apical endosomes in the developing wing epithelial cells. During mitosis, the Sara endosomes and the receptors therein associated with the spindle machinery to segregate into the two daughter cells. Daughter cells thereby inherited equal amounts of signaling molecules and thus retained the Dpp signaling levels of the mother cell.