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Thin layer chromatography—mass spectrometry using infrared lase desorption

1994; Elsevier BV; Volume: 140; Issue: 1 Linguagem: Inglês

10.1016/0168-1176(94)04084-2

1873-2801

Tanaz Fanibanda, John Milnes, John Gormally,

Analytical chemistry methods development

Abstract The infrared laser desorption of the drug naproxen from silica thin layer chromatography (TLC) plates is described. Desorbed neutral molecules were ionized by two-photon ionization at a wavelength of 266 nm and mass spectra were recorded using a time-of-flight mass spectrometer. Particular features investigated were the sensitivity attainable and the effect of repeated irradiation of the same area of the TLC plate.