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Artigo Produção Nacional
BIBTEX RIS

Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi

1978; Elsevier BV; Volume: 61; Issue: 2 Linguagem: Inglês

10.1016/0306-4492(78)90063-1

ISSN

1878-1969

Autores

Alberto Boveris, A.O.M. Stoppani, Roberto Docampo, Fernando S. Cruz,

Tópico(s)

Synthesis and Biological Evaluation

Resumo

1. O2− production is involved in the toxic action of naphthoquinones against Trypanosoma cruzi as is inferred from the correlation between quinone effect upon growth and the rate of O2− release from quinone-treated epimastigotes. 2. Mitochondrial membranes contribute to O2− generation in naphthoquinone-treated T. cruzi epimastigotes as is suggested by the correlation between the release of O2− from intact cells and the formation of O2− from the mitochondrial fraction.

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