Portal de Periódicos da CAPES

CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

2014; Hindawi Publishing Corporation; Volume: 2014; Linguagem: Inglês

10.1155/2014/768758

2314-6141

Matteo Santoni, Sergio Bracarda, Massimo Nabissi, Francesco Massari, Alessandro Conti, Emilio Bria, Giampaolo Tortora, Giorgio Santoni, Stefano Cascinu,

Angiogenesis and VEGF in Cancer

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.