DQ β sequences in HLA-DR4 haplotypes
1987; Elsevier BV; Volume: 18; Issue: 4 Linguagem: Inglês
10.1016/0198-8859(87)90073-5
ISSN1879-1166
AutoresJoanne M. Hilden, Julie Curtsinger, J. Scott Cairns, Fritz H. Bach,
Tópico(s)T-cell and B-cell Immunology
ResumoA cDNA clone encoding the entire mature DQ beta chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ beta sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ beta sequence polymorphism within this serotype (to date, DQ beta sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.
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