VASOACTIVE INTESTINAL PEPTIDE AND WATERY-DIARRHŒA SYNDROME
1973; Elsevier BV; Volume: 302; Issue: 7819 Linguagem: Inglês
10.1016/s0140-6736(73)91947-8
ISSN1474-547X
AutoresS.R. Bloom, JuliaM. Polak, A. G. E. Pearse,
Tópico(s)Pancreatic function and diabetes
ResumoSix patients with the watery-diarrhœa syndrome (pancreatic cholera) were found to have raised plasma levels and/or high tumour content of vasoactive intestinal peptide (V.I.P.), as measured by a specific radioimmunoassay. Positive immunofluorescence with V.I.P. antisera was obtained in two cases in which properly fixed tumour material was available. The known actions of V.I.P. accord well with the abnormalities found in the watery-diarrhœa syndrome. The availability of a plasma-V.I.P. assay may enable the diagnosis to be made before tumour metastasis occurs.
Referência(s)