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Neuroendocrine and Cardiovascular Effects of MDE in Healthy Volunteers

1993; Springer Nature; Volume: 8; Issue: 3 Linguagem: Inglês

10.1038/npp.1993.20

1740-634X

Euphrosyne Gouzoulis, U. von Bardeleben, Armin Rupp, Karl-Arthur Kovar, Leopold Hermle,

Stress Responses and Cortisol

The drug 3,4-methylenedioxyethamphetamine ([MDE] also known as "Eve") is a less toxic analog of 3,4-methylenedioxymethamphetamine (also known as "Ecstasy") with similar psychotropic effects in humans. In a double-blind placebo-controlled, cross-over study we administered 140 mg of MDE or placebo orally to eight healthy male volunteers at 1:30 P.M. Serum cortisol, prolactin (PRL), and growth hormone (GH) levels, as well as blood pressure, and heart rate were measured every 20 minutes until 5:00 P.M. Administration of MDE was followed by statistically significant long-lasting increases of serum cortisol, PRL, systolic blood pressure, and heart rate, and by a trend toward blunting of GH secretion. The neuroendocrine and cardiovascular effects of MDE are comparable to those of other phenethyl-amines with the exception of the effect on GH secretion.