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Functional Antibody CDR3 Fusion Proteins with Enhanced Pharmacological Properties

2013; Wiley; Volume: 52; Issue: 32 Linguagem: Inglês

10.1002/anie.201303656

1521-3773

Yong Zhang, Danling Wang, Lorenzo de Lichtervelde, Sophie Sun, Vaughn V. Smider, Peter G. Schultz, Feng Wang,

Protein purification and stability

Real staying power: A subset of bovine antibodies (blue, see scheme) feature an ultralong CDR3 loop that forms an antiparallel β-sheet stalk, terminating in a folded, disulfide cross-linked knob domain. Fusion of a polypeptide (red) into this unique CDR3 motif provides a novel strategy for generating polypeptide therapeutics with enhanced pharmacokinetics and pharmacodynamics. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.