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Loss of DNA: A plausible molecular level explanation for crustacean neuropeptide gene evolution

2006; Elsevier BV; Volume: 28; Issue: 1 Linguagem: Inglês

10.1016/j.peptides.2006.09.021

1873-5169

Francisco Martínez‐Pérez, Darinka Durán-Gutiérrez, Luis Delaye, Arturo Becerra, Guadalupe Aguilar, Samuel Zinker,

Biochemical and Structural Characterization

Alignment of nucleotides of APGWamide, RPCH and AKH genes gives region stretches (common regions) present in all family member variants. Common regions were separated by gap sections in the larger variants of family members. Consensus sequences for single polynucleotides from virtual hybrid molecules of DNA were obtained by joining the common regions of DNA and deleting the extra DNA nucleotides. Conceptual translation of these virtual hybrids resulted in polypeptides similar to APGWamide, RPCH and the AKH pre-pro-peptide. Virtual polypeptides were also similar to LWamide and RFamide along hydras to mammals. DNA loss probably explains the origin of neuropeptides.