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National Bone Health Alliance Bone Turnover Marker Project: current practices and the need for US harmonization, standardization, and common reference ranges

2012; Springer Science+Business Media; Volume: 23; Issue: 10 Linguagem: Inglês

10.1007/s00198-012-2049-z

1433-2965

Douglas C. Bauer, John H. Krege, Nancy E. Lane, Eileen Leary, Cesar Libanati, Paul D. Miller, Gary L. Myers, S Silverman, Hubert W. Vesper, D. Lee, M Payette, Susan Randall,

Bone Metabolism and Diseases

This position paper reviews how the National Bone Health Alliance (NBHA) will execute a project to help assure health professionals of the clinical utility of bone turnover markers; the current clinical approaches concerning osteoporosis and the status and use of bone turnover markers in the USA; the rationale for focusing this effort around two specific bone turnover markers; the need to standardize bone marker sample collection procedures, reference ranges, and bone turnover marker assays in clinical laboratories; and the importance of harmonization for future research of bone turnover markers.