Portal de Periódicos da CAPES

The synthesis of chemotherapeutic agents. I.

1946; Elsevier BV; Volume: 35; Issue: 11 Linguagem: Inglês

10.1002/jps.3030351105

1930-2304

John E. Christian, Glenn L. Jenkins, Leroy C. Keagle, Jean Ann Crum,

Phenothiazines and Benzothiazines Synthesis and Activities

Investigation of 5,5′-diacetamido-8,8′-diquinolyl disulfide indicated that it possesses a relatively high antimalarial activity. The report of this activity stimulated interest in the possible chemotherapeutic value of certain related thio and dithio compounds. This paper, the first of a series, describes the synthesis of sixteen compounds, eight of which are new, related to 5,5′-diacetamido-8,8′-diquinolyl disulfide. Twelve of these compounds were tested for antimalarial activity and the results of these tests are tabulated. In addition some of the compounds were also subjected to screening tests against Trypanosoma brucei, influenza virus and tetanus toxin.