Effect of imipramine on serotonin turnover in the lateral hypothalamus
1978; Elsevier BV; Volume: 9; Issue: 5 Linguagem: Inglês
10.1016/0091-3057(78)90223-x
ISSN1873-5177
AutoresKathleen M. Kantak, M.J. Wayner, J.M. Stein, H.A. Tilson,
Tópico(s)Biochemical Analysis and Sensing Techniques
ResumoOne hour following an infusion of 3H-5-hydroxytryptamine, animals were injected with either 15 mg/kg imipramine hydrochloride or 0.9% NaCl and then the lateral hypothalamus was perfused for 40 min. Samples of perfusate were analyzed by thin layer chromatography for estimation of 3H-labelled 5-hydroxytryptamine and metabolites. The results indicate that impramine hydrochloride 15 mg/kg decreases serotonin release and turnover in the lateral hypothalamus.
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