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Anticancer Constituents from the Roots of Rubia cordifolia L.

2008; Pharmaceutical Society of Japan; Volume: 56; Issue: 2 Linguagem: Inglês

10.1248/cpb.56.213

1347-5223

Jong Keun Son, Soon Ja Jung, Ji Hyun Jung, Zhe Fang, Chong Soon Lee, Chang‐Seob Seo, Dong Cheul Moon, Byung Sun Min, Mi Ryeo Kim, Mi Hee Woo,

Pharmacological Effects of Natural Compounds

Activity-directed isolation of the methylene chloride fraction of the roots of Rubia cordifolia L. resulted in the identification of a new epoxymollugin (3) and eight known compounds (1, 2, 4-9). The structures of the compounds were elucidated from chemical and spectroscopic evidence. In addition, their topoisomerase I and II inhibitory activities and cytotoxicities were measured.