Produção Nacional
Revisado por pares
Effects of Parboiled Rice Diet on Oxidative Stress Parameters in Kidney of Rats with Streptozotocin-Induced Diabetes
2012; Mary Ann Liebert, Inc.; Volume: 15; Issue: 7 Linguagem: Inglês
10.1089/jmf.2011.0306
ISSN1557-7600
AutoresIsabela Finamor, Etiane M.H. Saccol, Diogo Gabriel, Giovana M. Ourique, Ana Paula Konzen Riffel, Signorá Peres Konrad, Adriane Belló‐Klein, Wania Aparecida Partata, Bernardo Baldisserotto, Susana Llesuy, Maria A. Pavanato,
Tópico(s)Natural Antidiabetic Agents Studies
ResumoThe effect of parboiled rice (PR) and white rice (WR) diets on oxidative stress (OS) parameters was investigated in the kidneys of rats with streptozotocin-induced diabetes (40 mg kg−1, iv). The experimental groups (n=8) were control fed with PR (CPR), control fed with WR, diabetic fed with PR, and diabetic fed with WR. After 30 days of treatment, all animals were anesthetized and exsanguinated before removal of kidneys, which were used to determine thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides, carbonyl protein, superoxide dismutase, catalase, glutathione peroxidase (GPx), glutathione reductase, glutathione-S-transferase activities, and levels of glutathione (GSH). Total phenolic compounds were determined in WR and PR grains. Our data indicated that diabetes induced increase in TBARS and lipid hydroperoxides levels. Although PR has not prevented the rise in the levels of these measurements, its consumption by our animals resulted in higher GPx activity and GSH content than that of the CPR. Moreover, PR also presented concentration of total phenolic compounds 127% higher than WR grains. Thus, its consumption in this diabetic condition is suggested because this seems to confer greater protection against OS in the renal tissue of diabetic animals.
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