Pentamidine isethionate delivery from jet nebulisers
1992; Elsevier BV; Volume: 85; Issue: 1-3 Linguagem: Inglês
10.1016/0378-5173(92)90150-z
ISSN1873-3476
AutoresKevin Taylor, Geraldine Venthoye, Apporva Chawla,
Tópico(s)Acoustic Wave Resonator Technologies
ResumoAbstract This study has investigated the properties of aerosols of pentamidine isethionate produced by two jet nebulisers commonly used in clinical practice. The size characteristics of the emitted aerosols varied throughout the time that drug solutions were nebulised, particularly at low gas flow rates. The aqueous solubility of pentamidine isethionate was found to be highly temperature dependent. As the temperature of solutions within the nebulisers decreased by up to 13°C, recrystallization of drug occurred. Approx. 50% of drug available in the nebuliser was available for delivery from the nebulisers, the remainder being associated with the devices.
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