Portal de Periódicos da CAPES

Radiation Nephropathy is not Mitigated by Antagonists of Oxidative Stress

2009; Radiation Research Society; Volume: 172; Issue: 2 Linguagem: Inglês

10.1667/rr1739

1938-5404

Eric P. Cohen, Brian L. Fish, Amy A. Irving, Mohan Rajapurkar, Sudhir V. Shah, John E. Moulder,

Chemotherapy-induced organ toxicity mitigation

Abstract Persistent, chronic oxidative injury may play a mechanistic role in late radiation injury. Thus antioxidants may be useful as mitigators of radiation injury. The antioxidants deferiprone, genistein and apocynin were tested in a rat radiation nephropathy model that uses single-fraction total-body irradiation (TBI) followed by syngeneic bone marrow transplant. Deferiprone was added to the drinking water at 1.0 or 2.5 g/liter, starting 3 days after the TBI. Urinary bleomycin-detectable iron, which could enhance production of oxygen radicals, was reduced in the rats on deferiprone compared to untreated rats, but deferiprone did not mitigate radiation nephropathy. Genistein added to the chow at 750 mg/kg starting immediately after TBI did not mitigate radiation nephropathy. Apocynin added to the drinking water at 250 mg/liter immediately after TBI did not mitigate radiation nephropathy. Thus three different types of antioxidants, when used at doses consistent with an antioxidant effect, had no mitigation efficacy against radiation nephropathy.