Highly enantioselective reduction of achiral ketones with NaBH4/Me3SiCl catalyzed by (S)-α,α-diphenylpyrrolidinemethanol
2000; Elsevier BV; Volume: 41; Issue: 52 Linguagem: Inglês
10.1016/s0040-4039(00)01848-7
ISSN1873-3581
AutoresBiao Jiang, Yan Feng, Jian Zheng,
Tópico(s)Surface Chemistry and Catalysis
ResumoThe reducing agent prepared from sodium borohydride, trimethylsilyl chloride and a catalytic amount of (S)-α,α-diphenylpyrrolidinemethanol has been successfully applied to the enantioselective reduction of ketones. The optically active secondary alcohols were obtained in excellent enantiomeric excess and almost quantitative chemical yield.
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