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Haploidentical Bone Marrow Transplantation in Primary Immune Deficiency: Stem Cell Selection and Manipulation

2011; Elsevier BV; Volume: 25; Issue: 1 Linguagem: Inglês

10.1016/j.hoc.2010.11.004

1558-1977

David Hagin, Yaīr Reisner,

Immune Cell Function and Interaction

Since the early 1980s T-cell depletion has allowed haploidentical bone marrow transplantation to be performed in patients with primary immunodeficiency for whom a matched sibling donor was not available, without causing severe graft versus host disease (GVHD). This review article presents the available data in the literature on survival, GVHD, and immune reconstitution in different categories of patients, with special emphasis on the impact of different T-cell depletion methods.