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Hsp60 and Hsp10 as antitumour molecular agents

2007; Taylor & Francis; Volume: 6; Issue: 4 Linguagem: Inglês

10.4161/cbt.6.4.4087

1555-8576

Francesco Cappello, Anna M. Czarnecka, Giampiero La Rocca, Antonino Di Stefano, Giovanni Zummo, Alberto J.L. Macario,

Computational Drug Discovery Methods

The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example in rheumatoid arthritis. In view of these findings we want now to call attention to the potential of Hsp60 and Hsp10 in cancer therapy.