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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations

2014; Elsevier BV; Volume: 124; Issue: 9 Linguagem: Inglês

10.1182/blood-2014-04-571018

ISSN

1528-0020

Autores

Jean‐Baptiste Micol, Nicolas Duployez, Nicolas Boissel, Arnaud Petit, Sandrine Geffroy, Olivier Nibourel, Catherine Lacombe, Hélène Lapillonne, Pascaline Etancelin, Martin Figeac, Aline Renneville, Sylvie Castaigné, Guy Leverger, Norbert Ifrah, Hervé Dombret, Claude Preudhomme, Omar Abdel‐Wahab, Éric Jourdan,

Tópico(s)

Genomics and Chromatin Dynamics

Resumo

Key Points ASXL2 was mutated in 22.7% (25/110) of adult and pediatric t(8;21)/RUNX1-RUNX1T1 acute myeloid leukemia patients. ASXL2 mutations are mutually exclusive with ASXL1 mutations and occur in t(8;21) but not inv(16)/t(16;16) or RUNX1-mutant AML.

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