Tetracycline in Uranyl Nitrate Intoxication
1989; Lippincott Williams & Wilkins; Volume: 57; Issue: 3 Linguagem: Inglês
10.1097/00004032-198909000-00005
ISSN1538-5159
AutoresM.B. Guglielmotti, A. M. Ubios, JOSE ALEJANDRO GARCIA LARUMBE, R. L. Cabrini,
Tópico(s)Radiation Dose and Imaging
ResumoIn acute intoxication, uranium (U) not only inhibits bone formation but its excretion in urine also causes renal damage. The former effect is ameliorated by tetracycline (TC), probably due to its chelation property, which might also prevent U deposition in bone. Chemical determination of U incorporated in bone and a histological study of the kidneys were performed on animals injected with U and then treated with TC. The results showed that TC was unable to prevent the binding of U to bone while it exacerbated U-induced renal damage.
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