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Fertility after discontinuation of treatment with an oral contraceptive containing 30 μg of ethinyl estradiol and 2 mg of dienogest

2006; Elsevier BV; Volume: 85; Issue: 6 Linguagem: Inglês

10.1016/j.fertnstert.2005.11.052

1556-5653

Inka Wiegratz, Katrin Mittmann, H. Dietrich, Thomas Zimmermann, Herbert Kühl,

Pregnancy and Medication Impact

To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG).Prospective observational study.Population-based cohort in Germany.Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG).None.Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy.After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16-18 years), a certain delay was observed in the other age groups.The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception.