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DTP AND DTP‐INACTIVATED POLIO VACCINES: COMPARISON OF ADVERSE REACTIONS AND I g G, I g M and I g A ANTIBODY RESPONSES TO DTP

1980; Wiley; Volume: 69; Issue: 2 Linguagem: Inglês

10.1111/j.1651-2227.1980.tb07056.x

1651-2227

Olli Ruuskanen, Matti K. Viljanen, Toivo T. Salmi, Olli‐Pekka Lehtonen, K Kouvalainen, Tuomas Peltonen,

Herpesvirus Infections and Treatments

Abstract. Ruuskanen, O., Viljanen, M. K., Salmi, T. T., Lehtonen, O.‐P., Kouvalainen, K. and Peltonen, T. (Departments of Paediatrics and Medical Microbiology, University of Turku, and Department of Paediatrics, University of Oulu, Finland). DTP and DTP‐inactivated polio vaccines: comparison of adverse reactions and IgG, IgM and IgA antibody responses to DTP. Acta Paediatr Scand, 69:177, 1980.—Adverse reactions and anti‐DTP antibody responses were compared between DTP‐ or DTP‐inactivated‐polio‐vaccinated children. The material consisted of 380 children whose adverse reactions were registered by detailed questionnaires given to the parents. IgG‐, IgM‐ and IgA‐anti‐DTP antibodies of 42 children were quantified using enzyme‐linked immunosorbent assay (ELISA). Fever, restlessness and local reactions were the most frequent adverse reactions observed. DTP‐polio vaccine induced significantly more restlessness than DTP. This was the only significant difference in adverse reactions between the vaccines. An enhancement of IgG‐anti‐DTP antibody responses at the age of 6 months was observed in the DTP‐polio group. The enhancement was transient in antitoxin responses but still present in pertussis antibodies at 8 months of age. Very low and mostly undetectable levels of IgM‐ and IgA‐anti‐DTP antibodies were observed in both groups.