Preparation of ethyl 5(s),6-epoxy-3(r)-(methoxymethoxy)hexanoate: a key chiral intermediate for mevinolin and compactin.
1985; Elsevier BV; Volume: 26; Issue: 9 Linguagem: Inglês
10.1016/s0040-4039(00)98429-6
ISSN1873-3581
AutoresYvan Guindon, Christiane Yoakim, Michael A. Bernstein, Howard E. Morton,
Tópico(s)Biological Stains and Phytochemicals
ResumoThe synthesis of Ethyl 5(S),6-Epoxy-3(R)-(methoxymethoxy)hexanoate, a key chiral synthon for the β-hydroxy-δ-lactone portion of Mevinolin and Compactin, via a regiospecific ring opening of a tetrahydrofuran derivative by dimethylboron bromide, is described.
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