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Artigo Revisado por pares
BIBTEX RIS

Inconsistencies in Rationale Underlying Official USP Dissolution Rate Specifications for Nitrofurantoin

1973; Elsevier BV; Volume: 62; Issue: 12 Linguagem: Inglês

10.1002/jps.2600621241

ISSN

1520-6017

Autores

Theodore R. Bates, Howard A. Rosenberg, Aubrey V. Tembo,

Tópico(s)

Urinary Tract Infections Management

Resumo

Abstract Nitrofurantoin, l-[(5-nitrofurfurylidene)amino] hydantoin, is an antibacterial agent used clinically to treat specific urinary tract infections. Physiocochemically, the drug is a weak acid (pKa 7.2) possessing relatively low aqueous solubility characteristics at pH values normally encountered in the various segments of the GI tract of man. As a result, it is not surprising that the drug displays a particle-size dependence in its dissolution rate (1) and rate and extent of absorption (bioavailability) in man (1–4).

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