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BIBTEX RIS

A comparative study on the mechanism of the anticoagulant action of mollusc and mammalian heparins

1995; Elsevier BV; Volume: 111; Issue: 3 Linguagem: Inglês

10.1016/0300-9629(94)00021-k

ISSN

0300-9629

Autores

JoséF. Paiva, Elizeu Antunes dos Santos, Walter Jeske, Jawed Fareed, Helena B. Nader, Carl P. Dietrich,

Tópico(s)

Blood Coagulation and Thrombosis Mechanisms

Resumo

The anticlotting activities on some steps of the coagulation cascade of mollusc and mammalian heparins were studied. AT III-high affinity heparin is a more potent inhibitor than unfractionated heparin and mollusc heparin in the intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity as the AT III high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III and four times more inhibitory activity than unfractionated heparin on the heparin cofactor II mediated inhibition of thrombin.

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