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Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice

1999; Elsevier BV; Volume: 21; Issue: 5 Linguagem: Inglês

10.1016/s0192-0561(99)00013-2

1879-3495

Takafumi Hasegawa, Kazue Ito, Sugi Ueno, S. Kumamoto, Yukio Ando, Akira Yamada, K Nomoto, Y Yasunobu,

Escherichia coli research studies

Hot water extract of Chlorella vulgaris (CVE) is a biological response modifier (BRM) which enhances resistance to Listeria monocytogenes through augmentation of helper T cell type 1 (Thl) responses producing gamma-interferon (gammaIFN). We show here that oral administration of CVE in mice suppressed the production of immunoglobulin (Ig)E against casein antigen accompanied by increased gammaIFN and IL-12 mRNA expression. Oral administration of CVE enhanced Thl response to casein in the spleen of casein immunized mice. CVE may be useful for prevention of allergic diseases with a predominant Th2 response.