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Pharmacokinetics of Ciprofloxacin in Liver Cirrhosis

1990; Karger Publishers; Volume: 36; Issue: 6 Linguagem: Inglês

10.1159/000238793

1421-9794

Markus Ruhnke, Matthias Trautmann, Klaus Borner, W. Hopfenmüller,

Liver Disease and Transplantation

The pharmacokinetics of ciprofloxacin were evaluated in 11 patients (3 patients with impaired renal function) with advanced liver cirrhosis after a single oral dose of 500 mg. Mean serum peaks were 2.80 +/- 1.00 mg/l in 64 +/- 37 min after intake in patients with normal renal function. Elimination was reduced in comparison with healthy volunteers: t1/2 beta 510 +/- 158 min with a total area under the curve of 18.2 +/- 10.3 mg x h/l. Mean recovery of the parent compound from urine was 38 +/- 9% of the dose. In 3 patients with cirrhosis plus poor renal function, elimination was markedly reduced. In patients under 60 years with good renal function, the standard does not require a reduction.