Total synthesis of modified jstx toxins: reductive alkylation is a practical route to hexahydropyrimidine polyamine amides
1995; Elsevier BV; Volume: 36; Issue: 51 Linguagem: Inglês
10.1016/0040-4039(95)01995-t
ISSN1873-3581
AutoresMark Ashton, Eduardo Moya, Ian S. Blagbrough,
Tópico(s)Chemical Synthesis and Analysis
ResumoReductive alkylation is a practical route for a total synthesis of regioisomers of spider toxin JSTX-3, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. The strategy is based upon a reductive alkylation step which enables one free araine to be generated regiospecifically in the new polyamine, or the regiospecific incorporation of a hexahydropyrimidine moiety which conformationally restricts the polyamine amide backbone.
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