Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: Pathologic and molecular studies
2000; Elsevier BV; Volume: 137; Issue: 4 Linguagem: Inglês
10.1067/mpd.2000.108437
ISSN1097-6833
AutoresHortensia Mircescu, Jasmine Parma, Céline Huot, Cheri Deal, Luc L. Oligny, Gilbert Vassart, Guy Van Vliet,
Tópico(s)Cancer-related Molecular Pathways
ResumoWe identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia. (J Pediatr 2000;137:585-7)
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