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Síntese de novas amidas graxas a partir da aminólise de ésteres metílicos

2010; Brazilian Chemical Society; Volume: 33; Issue: 6 Linguagem: Inglês

10.1590/s0100-40422010000600022

1678-7064

Carolina Rosa Lopes, Caroline Da Ros Montes D’Oca, Rodrigo da Costa Duarte, Márcia H. S. Kurz, Ednei Gilberto Prímel, Rosilene Maria Clementin, Joaquín Ariel Morón Villarreyes, Marcelo G. Montes D’Oca,

Enzyme Catalysis and Immobilization

ACIDS AMIDES FROM AMINOLYSIS OF FAMES.Recent biochemical and pharmacological studies have led to the characterization of different fatty acid amides as a new family of biologically active lipids.Here, we describe the synthesis of new amides from C16:0, 18:0, 18:1 and 18:1, OH fatty acids (FFA) families with cyclic and acyclic amines and demonstrate for the first time that these compounds produce citotoxic effects.Application of this method to the synthesis of fatty acid amides was performed using the esters aminolysis as a key step and various carboxylic amides were prepared in good yield from fatty acid methyl esters (FAMEs).