Fabrication and testing of vaginal contraceptive devices designed for release of prespecified dose levels of steroids
1978; Elsevier BV; Volume: 17; Issue: 3 Linguagem: Inglês
10.1016/0010-7824(78)90013-6
ISSN1879-0518
AutoresF.G. Burton, W.E. Skiens, Nicolas Gordon, Jack T. Veal, D.R. Kalkwarf, Gordon W. Duncan,
Tópico(s)Reproductive Health and Contraception
ResumoSilicone rubber vaginal devices of six different formulations releasing predetermined, controlled doses of progestogens were designed and fabricated for 90-day clinical trials. Data obtained with 78 of the devices indicated that release rates (μg/day ± S.D.) for the formulations were: progesterone, 4040 ± 150, 1490 ± 100, 1440 ± 70; d-norgestrel, 188 ± 20, 41 ± 8; norethindrone, 479 ± 35. The release rates agreed well with release rates obtained .
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