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The Encephautogenic Dose Response in Guinea Pigs of the Tryptophan Region of Myelin Basic Protein

1974; Marcel Dekker; Volume: 3; Issue: 3 Linguagem: Inglês

10.3109/08820137409057319

0090-0877

Janis Dillaha Young, Dorinne Tsuchiya, Michael Geier, Steven S. Geier, Fred C. Westall, Millie Thompson, Richard J. Cyr, Elsie N. Ward, Francis Yurochko,

Neuropeptides and Animal Physiology

AbstractThe encephalitogenic dose response for the synthetic tryptophan peptide from the basic protein of myelin is given. The best dose in guinea pigs for disease induction using the peptide is between 1 and 3üg. Using doses higher or lower induces EAE in fewer animals.