Asymmetric hydrosilylation of dihydrofurans by use of palladium-MOP catalyst
1993; Elsevier BV; Volume: 34; Issue: 14 Linguagem: Inglês
10.1016/s0040-4039(00)77607-6
ISSN1873-3581
AutoresYasuhiro Uozumi, Tamio Hayashi,
Tópico(s)Chemical synthesis and alkaloids
ResumoCatalytic asymmetric hydrosilylation of dihydrofuran derivatives including 7-oxabicyclo[2.2.1]heptenes with trichlorosilane proceeded in the presence of 0.1 mol% of palladium catalyst bearing (R)-2-methoxy-2′-diphenylphosphino-1,1′-binaphthyl ((R)-MOP) to give the corresponding hydrosilylation products of up to 95% ee. A regioselective opening of the bicyclic system gave a highly functionalized cyclohexane in an optically active form.
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