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Percutaneous urinary diversion in gynecologic oncology

1990; Elsevier BV; Volume: 40; Issue: 3 Linguagem: Inglês

10.1016/0090-8258(90)90286-t

1095-6859

Jonathan Carter, Corazon Ramirez, Richard Waugh, Kenneth Atkinson, Malcolm Coppleson, Peter Elliott, John G. Murray, John Solomon, Christopher Dalrymple, Martin Tattersall, Peter Duval, Peter Russell, Norelle Lickiss,

Renal cell carcinoma treatment

During the 10-year period after 1979, percutaneous urinary diversion (PCUD) was performed on 35 patients whose mean age was 53.5 years (30–80 years). Twenty-one patients (60%) had Stage IIB-IV cervical cancer, 11 (31%) Stage IB-IIA cervical cancer, 2 (6%) Stage IB-II endometrial cancer, and 1 (3%) Stage IB vaginal cancer. All had radiological evidence of ureteric obstruction and 8 patients also had urinary tract fistulae. Serum creatinine levels were elevated in 24. Following diversion there was a significant fall in mean pretreatment creatinine levels from 482 μmole/liter (range, 70–1703 μmole/liter) to 131 μmole/liter (range, 60–290 μmole/liter; P < 0.0001); those patients with normal creatinine levels prior to diversion also had a reduction in their levels. A significant fall in mean serum urea levels from 22.0 mmole/liter pre- to 11.9 mmole/liter post-PCUD (P < 0.001) was also noted. Minor complications occurred and included hemorrhage, replacement/reinsertion, infection, and blockage. Median survival of the 35 patients after PCUD was 6 months (mean, 16.5 months). For the 11 with normal pretreatment renal function median survival was 16 months (mean, 41 months) compared to 2.5 months (mean, 5.1 months) for those with elevated pretreatment serum creatinine levels. Median survival with untreated malignancy was 7 months (mean, 19.6 months) and 6 months (mean, 12.3 months) in patients with previously treated cancer. PCUD is indicated in previously untreated patients with gynecologic cancer so that primary therapy can be instituted. The role of urinary diversion in patients with previously treated cancer must be individualized. Palliative diversion is appropriate in selected patients where additional therapy is expected to prolong life, where symptom control is needed, or to allow the patient to return home for a significant proportion of the remainder of life.