IL‐1α and IL‐6 production by oral and skin keratinocytes: similarities and differences in response to cytokine treatment in vitro
1996; Wiley; Volume: 25; Issue: 4 Linguagem: Inglês
10.1111/j.1600-0714.1996.tb00213.x
ISSN1600-0714
AutoresJ. Li, Paula M. Farthing, Grenharn W. Ireland, Martin H. Thornhill,
Tópico(s)Wound Healing and Treatments
ResumoIL‐1α and IL‐6 are important pro‐inflammatory and immunomodulatory cytokines and their production by oral (OK) and skin keratinocytes (SK) was compared. OK and SK produced IL‐la, but not IL‐6, constitutively. TNFα stimulation increased IL‐la production by both cell types and exhibited synergy with interferon y (IFNγ). although the latter had no effect by itself. In contrast, both cell types produced IL‐6 in response to TNFα, IFNγ or IL‐4. and IFNγ and IL‐4 exhibited synergy with TNFα. For all cytokines the levels of IL‐6 production were greater for OK than SK and OK, but not SK, produced IL‐6 in response to IL‐1α stimulation. In addition, the IL‐6 response to IL‐4 stimulation was more rapid for OK than SK. These observations may explain the similarities and differences in wound healing and immuno‐inflammatory diseases affecting the skin and oral mucosa.
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