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Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

2012; Royal Society of Chemistry; Volume: 12; Issue: 11 Linguagem: Inglês

10.1039/c2lc40157f

1473-0197

Renato S. Lima, Maria H. O. Piazzetta, Ângelo L. Gobbi, Ubirajara Pereira Rodrigues Filho, P.A.P. Nascente, Wendell K. T. Coltro, Emanuel Carrilho,

Electrochemical sensors and biosensors

We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. The device presents relevant advantages such as direct determination--dismiss the use of redox mediators as in faradaic electrochemical techniques--and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication.