Pyranocoumarins: A new class of anti-hyperglycemic and anti-dyslipidemic agents
2009; Elsevier BV; Volume: 19; Issue: 22 Linguagem: Inglês
10.1016/j.bmcl.2009.09.031
ISSN1464-3405
AutoresAtul Kumar, Ram Awatar Maurya, Siddharth Sharma, Pervez Ahmad, Amar Singh, Gitika Bhatia, Arvind K. Srivastava,
Tópico(s)Phytochemicals and Antioxidant Activities
ResumoA series of pyranocoumarin derivatives were synthesized and evaluated in vivo for their anti-hyperglycemic as well as anti-dyslipidemic activities. Compounds 7a, 7c, 8a, 8b, 8c, 8e and 8f have shown promising anti-hyperglycemic activities in sucrose loaded model (SLM) as well as sucrose challenged streptozotocin induced diabetic rat model (STZ). Compounds 8a and 8b were showing 38.0% and 42.0% blood glucose lowering activity in db/db mice model. In vitro anti-hyperglycemic activity evaluation exhibited that compounds 8a (IC50 = 24.5 μM) and 8b (IC50 = 36.2 μM) are potential PTP-1B inhibitors thereby revealing their possible mechanism of anti-diabetic action. Compounds 7a, 7b, 8a, 8b, 8d, 8e and 8f have shown significant anti-dyslipidemic activity in triton induced dyslipidemia in rats.
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